PITUITARY ADRENOCORTICOTROPIC ACTIVITY IN ALTERED THYROID FUNCTION

Pituitary adrenocorticotropic activity in altered thyroid function.

Alteration in thyroid state influenced the rate of metabolism of adrenocortical hormone by rats liver tissue in vitro, with proportional change in adrenal weight(Yates, 1958). These experiments suggest that the thyroid function would determine the rate of ACTH secretion in unstressed animals. The present study was undertaken to explore the possibility of difference in pituitary-adrenocortical s...

The Pituitary-Thyroid Axis in Acromegaly

The pituitary-Thyroid axis of 12 Acromegalic patients was evaluated by measurement of the concentration (Total and free of thyroxine T4, T3 and revers T3 (rT3) and TSH, GH and prolactin before and after in stimulation with TRH. Using an ultra­sensitive method of TSH measurement (IRMA) basal serum TSH levels of patients (0.76, 0.07-l.90mlU/L) were found slightly but significantly (P < 0.01), low...

Pituitary Adrenocorticotropic Hormone Secretion in Humans

To clarify the physiological role of placental corticotropin-releasing hormone (CRH), we measured plasma CRH, ACTH, and cortisol throughout pregnancy. Cerebrospinal fluid (CSF) CRH levels and ACTH responsiveness to synthetic CRH were also quantified in pregnant and nonpregnant women. Maternal plasma CRH levels, which increased progressively during pregnancy, correlated well with both ACTH and c...

How Are Thyroid Function Tests Altered by Thyroid Replacement Medications?

Altered Pituitary Gland Structure and Function in Posttraumatic Stress Disorder

Objectives Posttraumatic stress disorder (PTSD) is associated with hypothalamus-pituitary-adrenal (HPA) axis response to stressors, but links to neurophysiological and neuroanatomical changes are unclear. The purpose of this study was to determine whether stress-induced cortisol alters negative feedback on pituitary corticotroph function and pituitary volume. Design Prospective controlled stu...